Additional Research Studies Being Conducted by the ITN
Autoimmune Disease Clinical Trials
BRAVOS is a clinical trial evaluating Brentuximab Vendotin treatment for Diffuse Cutaneous Systemic Sclerosis.
The primary goal of the REVEAL study is to determine whether the experimental study medication, AMG 714, can bring back normal color to the skin (repigmentation) in vitiligo.
The REBOOT study will test whether a combination of belimumab and rituximab is safe and if this combination is more effective at blocking the immune attack on the kidney in patients with Primary Membranous Neuropathy compared to rituximab alone.
This study is to compare chemotherapy followed by autologous hematopoietic stem cell transplant (AHSCT) – a type of bone marrow transplantation – to the most effective medicines regularly used to treat relapsing MS
Allergy Clinical Trials
ACTIVATE is a clinical trial investigating the impact of the infant microbiome on allergy development.
LEAP Trio is a follow-up to the LEAP study of early peanut consumption. LEAP Trio will investigate the durability of tolerance to peanut allergen in LEAP participants at age 12, development of peanut allergy in younger siblings of LEAP participants, and parental characteristics that may impact development of food allergy.
Transplantation Clinical Trials
TEACH is a clinical trial investigating whether cells from the kidney donor’s bone marrow, called mesenchymal stromal cells (MSCs) will allow kidney transplant recipients to stop immunosuppressive medications.
LITTMUS is a clinical research study testing a new approach to achieve transplant tolerance using the liver transplant recipient’s own T regulatory cells (Tregs).
ALLTOL is an observational clinical study to learn more about tolerance in organ transplantation.
Type 1 Diabetes Clinical Trials
The EXTEND study is a clinical research study testing whether tocilizumab (Actemra ®) can protect remaining beta cells in individuals recently diagnosed with type 1 diabetes and extend the ability to naturally produce insulin.
T1DES is a clinical study for people with type 1 diabetes who were previously enrolled in an ITN clinical study.
For more information about the ITN and other clinical trials, please visit immunetolerance.org.